When times are tough and families are struggling, the first impulse is probably not to go on vacation.

But sometimes, that’s just what people need, whether they’re struggling with multiple sclerosis, battling breast cancer or dealing with a family member deployed to a war zone.

These are vacations with a heart. These are vacations that can heal. These are vacations that can change lives.

Watch as Meredith Vieira and Peter Greenberg discuss Vacations With a Heart.

Among the great vacation spots mentioned in this clip are Jackson, New Hampshire, where the Inn at Jackson leads the town in opening its doors to those dealing with multiple sclerosis.

There’s also OperationVacation.org, which helps soldiers reunite with their families for ‘long weekend’ vacations. CastingforRecovery.org helps women fighting (or recovering from) breast cancer to use fly fishing for not only fun, but physical therapy.

Faith’s Lodge, an 80-acre facility in Wisconsin, caters to kids and families struggling with illnesses and loss.

Watch more clips from the Today show.

Check out more video travel tips on Peter’s official YouTube channel.