Hipmunk has released some new data showing that October is your most affordable time for a weekend getaway from now until the end of 2012. And this weekend is the cheapest weekend to get away. And the cheapest city to get away to on that weekend is St. Louis, where average fares from the country’s busiest airport start at just $59. In November, the weekends of the second and ninth are the most affordable options. After that the minimum price can jump by as much as 700 percent.

To get a head start, right now Virgin America has a 48-hour sale on nonstop fares from New York, Los Angeles, San Francisco, Portland, Seattle, Boston, Orlando, Philadelphia, Fort Lauderdale, Dallas-Fort Worth and Washington, D.C.

And the savings are even for flights into 2013. The sale starts for flights as of October 22 and goes until February 13 with black outs dates for major holidays.

The sale ends at 11:59 pm CT on Wednesday, October 3.

Sample one-way fares include:

  • San Francisco to Las Vegas for $69
  • Chicago to San Francisco for $139
  • Philadelphia to Los Angeles for $139
  • Boston to San Francisco for $159
  • Washington, D.C to Los Angeles for $149
  • New York to Las Vegas for $169

Click here for more information.